Ceribus

Navigator Genome Pilot is an agentic RESEARCH tool for rare-disease variant interpretation — not a diagnostic system and not medical advice. Diagnosing a rare genetic disease means taking a list of candidate DNA variants and a messy clinical picture and cross-checking them against genetics databases, population-frequency data, phenotype ontologies, and the published literature — days of expert work per case. Navigator runs that investigation as eight specialized AI agents, each in its own isolated context, coordinated into a single sourced evidence dossier: Intake (parses/normalizes the VCF), Filtering (reduces candidates by population frequency and quality, explaining every exclusion), Phenotype (maps the clinical picture to HPO terms via the live JAX ontology API), Literature (Europe PMC, every claim carrying a real PMID/DOI), Database (live MyVariant.info / ClinVar / gnomAD), Case-Matching (compares to solved cases), Red Team (runs isolated, never sees the leading hypothesis, and argues against the conclusion), and Dossier Writer (assembles a ranked, physician-facing PDF). The output is never a verdict — it is a ranked, cited, uncertainty-labeled dossier: the top candidate gene/variant, supporting evidence with sources, the contradicting evidence, and an explicit statement of what remains unknown. Every row is tagged Idea/Designed/Implemented/Verified or explicitly Unknown; a missing database record is labeled "absent, not benign"; when a source is down, the dossier says so rather than guessing. It is benchmarked only on already-solved public cases with the answer hidden — measuring a research protocol, not advising a person. Proof: top-1 = 100% and top-5 = 100% over 15 published solved cases (CFTR, DMD, LDLR, BRCA1, HTT, F8, FBN1, PAH, GAA, MECP2, HBB, SMN1, HEXA, VHL, ATP7B), every expected gene ranked #1, across 63 real Meta Model API completions with zero failures. Navigator is also one laboratory on a general architecture (deterministic data reduction → isolated Meta-Muse expert agents → adversarial red-team → cited dossier). The same spine powers a roadmap of verticals — Media, Government, Research, Corporate Intelligence, and Patent Navigators — by swapping only the data sources and vocabulary. Only the Genome laboratory is live and benchmarked today; the rest are the platform roadmap.