RNA Optimization

We wanted to utilized and highlight the expanded GPT5 context window and improved hallucination. Thus for application, we attempted to optimize the RNA sequence for the spike protein (large sequence to utilize the larger context window) for thermal stability to skip the cold-chain transport requirements (we have 3rd party software to visualize the new structure to validate optimization). We were able to improve the temperature by 0.3C, not dramatic, but decent for such a large structure in 24hrs. The new structure (our startup has structure prediction and visualization software for RNA) was able to display the original and improved sequences to show that there are significantly fewer double-stranded RNA, which may decrease innate immune response but boost adaptive immune response which is more targeted and longer lasting. (We used the original spike protein sequence, not modified for efficiency, to ensure that this code doesn't land in the wrong hands).