HISTORA is a non-diagnostic, agentic clinical-research navigator built with Claude Code for a clinical/translational researcher. Testing a hypothesis like "does periodontal inflammation share mechanisms with cardiometabolic disease?" normally means weeks of chart review — and often the data isn't even there. HISTORA turns a fragmented public corpus (NHANES) into a research-ready cohort in seconds: an eligibility funnel (20,905 → 442), per-field completeness, and — the differentiator — it states what the data cannot answer (a missing datum is a collection flag, never imputed). It grounds one falsifiable, non-diagnostic hypothesis in genetics it runs live: IL-6R → coronary disease is genetically causal (replicated across FinnGen and BioBank Japan), circulating CRP is not, and the Alzheimer's axis stays exploratory. Operating its own pipeline under a reviewer agent, it caught, retracted, and fixed a bug in its own flagship number (+0.705 → +0.553), with a regression test. It's reproducible, tested, Apache-licensed software a lab can run without us in the room. Why it matters: the mouth is a cheap, modifiable window into the inflammation behind heart disease and diabetes — HISTORA is the instrument to study that link honestly.
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