In one week, I turned a biological question into a journal-ready paper and reproducible biomarker. IMMUNA-CD4 is a compact 17-gene measure of immune aging in naive CD4 T cells. I developed it using several cohorts and validated it in an independent population. It tracks age and is also linked to immune health after accounting for age. I then tested the biomarker in a genome-scale CRISPRi screen. This created a map of genes that may affect the measured aging signal. The final project includes a complete paper, figures, Source Data, analysis code, provenance, and a verified reproducible build.
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