MKTurkcan

Enactome is a connectome-constrained simulation platform that loads the BANC Drosophila connectome (composed of 158,262 neurons, 3,990,039 synapses), signs each synapse by its presynaptic transmitter, and evaluates circuit function through rate, integrate-and-fire, and Hodgkin-Huxley neuron models exposed as both an HTTP API and a desktop application. A registry of 35 connectome-derived experiments recreates published findings by simulation, establishing that the lateral horn compresses the odor representation (participation ratio 2.74 to 1.71, exceeding degree-preserving wiring shuffles at z = 6.2) with an aversion bias of roughly 2.2 to 1, and that the central-complex wiring settles to four discrete heading states rather than a continuous ring attractor. A gene-to-cell-type layer links circuits to human disease, showing that fly orthologs of epilepsy and Parkinson genes are enriched in neurons relative to size-matched panels, which matters because it converts a static wiring diagram into reproducible, auditable circuit hypotheses and a translational bridge to disease genetics.

Team

Placement

Participant