Sakintori
Built at Built with Claude: Life Sciences · Jul 7, 2026 · Remote

We built The Human Branch: a Claude Code agent that drives Claude Science as a headless lab and enforces the scientific method in code, so it cannot fool itself into calling a gBGC artifact a human innovation. Applied to Katie Pollard's Human Accelerated Regions, it takes each region from "looks accelerated" toward a testable mechanism. Why this matters: HARs look like human regulatory innovation, but GC-biased gene conversion (gBGC) forges the same signal and has produced false positives in published HAR work. So the discipline is structural, not a prompt. The conductor gates gBGC first, seals each protocol before it reads a result (a hash-chained notebook, not a promise), and never lets the data that picked a candidate also confirm it. What it found: one locus read clean in the cache but crossed the preregistered gBGC gate on the full 241-way alignment, as a flag, not a verdict, and not significant after correction. Another, ARMH3, drew orthogonal developmental contact support yet still capped at candidate, because contact is not cause. When the engine overclaimed, it caught and logged its own mistake. Every locus caps at candidate, and it says so.