Team Veritas

VERITAS is an independent verifier for AI-generated single-cell findings. A copilot says "gene X is up in Alzheimer's." VERITAS re-runs that claim across every defensible analysis choice the analyst didn't try, checks the experimental design for structural confounds, and returns a signed verdict: SURVIVES, DOES NOT SURVIVE, or UNVERIFIABLE. Every flag carries a re-derivable statistic, never a model opinion. The methods are real, not heuristics: donor-level DESeq2 pseudobulk, design-matrix batch models, Leiden, Harmony, Scrublet. Where a real method wasn't possible (ambient contamination needs empty-droplet data we never receive), we deleted the check rather than ship a proxy. What we found: pointing VERITAS at real published Alzheimer's cortex data exposed a false-green in VERITAS itself. A finding that broke only at the pseudobulk axis still scored 0.94 and was certified GREEN — the exact failure the tool exists to catch. We made pseudobulk a critical axis and wrote it up. Why it matters: Mathys et al. 2019 reported 14,274 Alzheimer's DEGs computed at the cell level. A donor-level reanalysis (eLife 2023) found 26. AI now generates findings faster than anyone can check them. Claude Science ships a reviewer, but it's the same model checking itself. VERITAS is the independent check: it re-runs the analysis and computes the number.

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