EVIDENTIA

Evidentia is a provenance-aware, longitudinal, clinical diagnosis hypothesis-generation and Bayesian ranking system with next-best clinical questioning. Data from clinical unstructured notes are extracted and normalized into Human Phenotype Ontology (HPO) terms and are reverse indexed search via the Monarch Initiative (symptoms-> disease ontology map) to generate a list of disease conditions. Reactome pathway look up establishes potential linkages that strengthen the claim of these constellation of symptoms, creating a ranking system per episode of care. As the notes progress over time, the weight of the evidence shifts accordingly, self-adapting to the greater clinical picture.