Biopilot Bench

BioPilot Bench is a Meta-powered scientific workbench that turns protein-variant requests into traceable reviews. It addresses a common research problem: sequence files, mutation constraints, model scores, structures and explanations are scattered across disconnected tools. In the current Lipase A workflow, researchers upload the registered public FASTA, describe a variant, validate the input and approve a bounded execution. Meta coordinates permitted MCP tools while Python enforces residue numbering, protected catalytic sites, call limits and a common ranking policy. ESM-2 scores all 19 non-WT alternatives at the selected position. Researchers can compare candidates, inspect an experimental reference structure, explore separately computed ESMFold2 WT and ESM3 A32V predictions, and review exact-reference Atlas context. Saved artifacts and tool traces connect each result to its inputs and execution history, helping researchers select hypotheses for follow-up experiments.