# Frontier gene writers

- **Event:** [Meta Global AI Developer Hackathon](https://cerebralvalley.ai/e/meta-ai-developer-hackathon)
- **When:** Oct 26, 12:00 PM – Nov 4, 9:00 PM (EST)
- **Where:** Online
- **Team:** [Jongwon Im](https://cerebralvalley.ai/u/Canyon)
- **GitHub:** https://github.com/impala9397-hub/frontier-gene-writers
- **Demo video:** https://drive.google.com/file/d/1D2LQjc5uYop9A4rReaoga8hYgO27Uq3j/view?usp=drivesdk
- **Gallery:** https://cerebralvalley.ai/e/meta-ai-developer-hackathon/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/meta-ai-developer-hackathon/hackathon/gallery/938

Frontier gene writers is an agentic pipeline that discovers programmable recombinases and transposases for therapeutic gene insertion. Precise insertion of large therapeutic DNA payloads remains a bottleneck for genetic medicines. The pipeline queries MGnify Proteins for serine-recombinase domains (Pfam PF00239 + PF07508 core, PF13408 bonus), intersects the two searches (34 candidates), ranks 20 by filter score plus a bounded tie-break, and uses an LLM review to judge the top candidates. In the demo run, the top two candidates tied at 4.850 (effectively co-leaders, near-duplicate homologs), and the smallest top candidate (509 aa) was judged most delivery-friendly. The work is 100% dry-lab: code only, no wet-lab validation.

## More from Meta Global AI Developer Hackathon

- [Inkwell](https://cerebralvalley.ai/e/meta-ai-developer-hackathon/hackathon/gallery/935)
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- [4N](https://cerebralvalley.ai/e/meta-ai-developer-hackathon/hackathon/gallery/939)
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- [Nimbus](https://cerebralvalley.ai/e/meta-ai-developer-hackathon/hackathon/gallery/941)

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Markdown version of https://cerebralvalley.ai/e/meta-ai-developer-hackathon/hackathon/gallery/938. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt