# ShiftScope (solo)

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Tina Shen](https://cerebralvalley.ai/u/Tina233)
- **GitHub:** https://github.com/aenorhabditis6/claude_science_hackathon/tree/main
- **Demo video:** https://youtu.be/eL98YqIpexQ
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/88

ShiftScope compares any two single-cell populations, measures how far apart they are, finds the genes driving the difference, and ranks which genes to test next. It is condition-agnostic, so the same tool handles perturbation, disease, development, or cell-type comparisons.
Its main use runs on Alex Marson's genome-scale CD4+ T-cell CRISPR screen. ShiftScope ranks hits by how strong the effect is and how little the gene has been studied, using a live PubMed count so novelty is grounded, not guessed. Claude then gives a keep-or-skip verdict. Famous regulators like VAV1 and CD45 drop; strong but overlooked genes, including chromatin-complex members with almost no papers, rise as candidates worth testing. It recovers correct biology across four domains and two real screens.
Why it matters: a screen yields thousands of hits but a lab can test only a few. These are hypothesis-generating nominations that point wet-lab effort toward high-value, overlooked biology.

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/88. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt