# Ken Kamiya

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [ken kamiya](https://cerebralvalley.ai/u/kkami1115)
- **GitHub:** https://github.com/kkami1115/morphoDE
- **Demo video:** https://youtu.be/h1vk-xAkmjY
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/66

morphoDE asks a deliberately simple question: where two cell types meet, the boundary bulges outward in some places and caves inward in others—do the cells on a bulge express different genes than the cells in a dent? We tested it across 11 published 3D spatial-transcriptomics datasets and 126 interface–strata, from a human lymph-node tumor to an Arabidopsis leaf.

The correspondence holds almost everywhere: 125 of 126 interface–strata carry signal that survives a geometry-breaking null (which shuffles the shape while keeping the biology fixed), signal appears in all 11 datasets, and 16 reach a perfect 12/12 in species sharing no common ancestry. On the human tumor the difference is 93% within a single cell type—convex bulges carry immune and cholesterol programs, concave dents carry hypoxia and invasion (PTHLH, KRT17).

Why it matters: interface shape and cell state are linked as a general property of tissue architecture, not a tumor quirk—giving a geometry-readable spatial map of cell state, from cancer to plants.

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