# Abraham

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Abraham Lin](https://cerebralvalley.ai/u/ALin7)
- **GitHub:** https://github.com/ALin-Orbits/Claude_Science_Hackathon
- **Demo video:** https://youtu.be/PGftJQQX3z8
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/288

Most locally advanced rectal cancers are mismatch-repair proficient and have no molecularly-guided treatment. We asked whether drugs that already exist could help, guided by the biology that makes these tumors resist chemoradiation.

Anchoring to the chemoradiation-resistance gene program (GSE209746), two independent engines — one by drug target, one by measured kinase binding — nominated 287 clinically-available drugs. A permutation test confirmed the anchor is non-arbitrary (p=0.001 vs 1,000 random gene sets). FDA-label safety filtering distilled this to two ranked shortlists of 44 drugs, ready for patient-derived organoid testing.

Claude drove the full scientific method: planning, building both engines, integrating eleven public databases, reasoning through methodology, drafting the manuscript, then acting as a critical peer reviewer that exposed weak claims — which we revised into a stronger, defensible result. One researcher, the complete arc of science.

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/288. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt