# Ruth-Anne Pai

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Ruth-Anne Pai](https://cerebralvalley.ai/u/Rpai)
- **Demo video:** https://youtu.be/GV9aKAsQ9I8
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/28

I took one disease from idea to an investable program in a week and then turned that workflow into open AI agents for any disease. It began with eosinophilic esophagitis (EoE), a chronic food-driven condition I live with. From public omics, I mined EoE datasets into a ranked, druggability-filtered target landscape (surfacing CCL26 and POSTN), designed de novo protein binders, and carried it through a business plan, scientific plan, and regulatory strategy. Knowing the burden of life-long symptom maintenance firsthand, I initiated Project Tolera, an antigen-specific program to reprogram the immune system: because EoE is a food peptide presented on MHC-II to a pathogenic Th2 T cell, targeting that triad could induce durable tolerance instead of lifelong suppression. My engine nominated 832 tolerizing epitopes and modeled lead pMHC-II complexes. Seeing the pipeline generalize, I packaged every step into reusable skills, a Therapeutic Program Architect, and a Manuscript Architect, then re-ran it on esophageal cancer as a test. I also built the Patient Organization Navigator: a specialist agent and three skills that help patient advocates and rare-disease nonprofits map where their disease stands, what's been done, where the gaps are, and where their funding and capacity sit.

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/28. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt