# Orca

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Kim Yeojin](https://cerebralvalley.ai/u/Orca)
- **GitHub:** https://github.com/YeojinKim220/perturb-to-spatial.git
- **Demo video:** https://www.youtube.com/
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/270

I built a transparent computational bridge from a genome-scale CD4⁺ T-cell Perturb-seq atlas (Marson–Pritchard CRISPRi, 4 donors, conditions Rest / Stim 8 h / Stim 48 h) to tumor spatial transcriptomics (CosMx NSCLC, 765,771 cells, 960-gene panel) to ask a two-part question: within a single annotated CD4⁺ T-cell type, do spatially distinct functional states exist, and can the Perturb-seq atlas nominate a different candidate regulator for each — respecting that a knockdown's effect depends on whether the T cell is resting or activated.

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/270. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt