# IMMUNA

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Fridolin Haugg](https://cerebralvalley.ai/u/frido)
- **GitHub:** https://github.com/frido22/immuna-cd4-paper
- **Demo video:** https://www.youtube.com/watch?v=oLNe4ucfsAg
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/25

In one week, I turned a biological question into a journal-ready paper and reproducible biomarker. IMMUNA-CD4 is a compact 17-gene measure of immune aging in naive CD4 T cells. I developed it using several cohorts and validated it in an independent population. It tracks age and is also linked to immune health after accounting for age. I then tested the biomarker in a genome-scale CRISPRi screen. This created a map of genes that may affect the measured aging signal. The final project includes a complete paper, figures, Source Data, analysis code, provenance, and a verified reproducible build.

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