# Sera

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [mohamed elrefaiy](https://cerebralvalley.ai/u/melrefaiy)
- **GitHub:** https://github.com/mohamedelrefaiy/Sera.git
- **Demo video:** https://drive.google.com/drive/folders/1Sk7tQv-5UU2HsjKtcpYxwRwjuNKu7BoL?usp=sharing
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/243

Sera helps target-discovery biologists decide which screen hits to advance. It reconciles a CRISPRi mRNA screen against a protein screen: for each gene and condition, do the readouts agree, or does one flag a hit the other misses? On Alex Marson's genome-scale CD4+ T-cell screen, Sera ranks 7,195 candidates, then has Claude challenge its own front-runners on donor/guide robustness, real knockdown, and statistical power, and shows the rejects. Take its top corroborated hit, NFKB2: the readouts agree at 8 hours, then split by 48, when only the protein screen flags it. That late, protein-only signal is the fingerprint of noncanonical NF-κB, which acts after transcription where an mRNA screen goes blind. Sera returns one call: advance or hold, plus the experiment that settles it.

The trust rule is simple: Claude reasons, but it never writes a fact. Deterministic code produces every number, identifier, and citation. Claude can only point, choosing a paper or structure by its position in a code-retrieved list, never typing a PMID or accession. It structurally cannot invent a reference. A controls-first gate also hides every novel pick until Sera first recovers the screen's known biology (5/5, both screens).

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/243. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt