# Pasteur

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Ricardo Pinho](https://cerebralvalley.ai/u/rpinho)
- **GitHub:** https://github.com/rpinho/louis
- **Demo video:** https://www.loom.com/share/4e9ab966e3c848828d0ebbe9b33c7b47
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/221

Louis is an MCP server + Slack bot that turns a genome-scale CD4⁺ T-cell CRISPRi Perturb-seq screen (Marson/Pritchard 2025) into a discovery-and-memory assistant living inside Claude — no separate app, no API key. Named for Pasteur, it discovers understudied, druggable regulator handles wired to a disease's own GWAS risk genes, gated by CRISPRi knockdown QC and activation state; run blind as a positive control, the same ranking re-derives the Th17 masters STAT3/BATF/IRF4 — 1 of 77 regulator clusters clears significance (Crohn's q=0.025): disease-calibrated, not a hub.

Its sharpest move is honesty. Handed its own flagship RA lead DOT1L, Louis stress-tests it A→C — the wiring is a cross-disease artifact, and because DOT1L props up regulatory T cells an inhibitor likely worsens RA — then returns the survivor, HDAC7 for Th17-driven colitis (favorable, peer-reviewed direction), with the go/no-go experiment. It weighs every source by provenance (a preprint is never decisive), reviews itself, and the whole lab writes back to a shared memory.

Why it matters: the bottleneck a bench scientist named isn't analysis — it's trust. A discovery tool that kills its own darling, with receipts, is one you can hand the survivors.

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/221. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt