# Clinibrium

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Manuel Pena Zuniga](https://cerebralvalley.ai/u/manuelpzdev)
- **GitHub:** https://github.com/manuelpenazuniga/Clinibrium
- **Demo video:** https://ioom.short.gy/5i5hNf72ywbwu2
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/214

Clinibrium is a clinical decision-support co-pilot for the otoneurology clinic, developed with a subspecialist otolaryngologist. It triages a common complaint — vertigo — that hides a rare emergency: posterior-circulation stroke. Its founding guarantee: the model never makes the safety call.

The architecture inverts the usual LLM app — deterministic layers own everything that must be trustworthy. A RedFlagEngine, physically separated from the differential, and hard rails seal the urgency verdict with escalate-only, monotone semantics. A CatBoost + SHAP confidence layer, trained on real clinical cases, doesn't touch urgency — it feeds a recommendation to Claude. Claude reasons over it, grounds its explanation in paraphrased ICVD criteria, and picks its own model (Opus for urgent cases, Sonnet for ambulatory). When Claude catches a subtlety the rules miss, it can raise the alert one level — never lower it. Kill the ML or Claude live and urgency doesn't change; we test exactly that.

Our most creative use of Claude Code is the Safety Harness: a hook that reruns invariant tests whenever Claude edits a safety-critical file and blocks the commit if a guarantee breaks, plus a skill that turns a specialist-signed rule into adversarially-tested code. Twelve invariants, +300 tests, multi-model adversarial audits, tamper-evident FHIR, on-device video. Specialist-reviewed; honestly scoped.

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/214. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt