# ParadoxMap

- **Event:** [Built with Claude: Life Sciences](https://cerebralvalley.ai/e/built-with-claude-life-sciences)
- **When:** Jul 7 at 12:00 PM – Jul 14 at 12:00 AM (EDT)
- **Where:** Online
- **Team:** [Jingyu Xie](https://cerebralvalley.ai/u/ValerieTse)
- **GitHub:** https://github.com/ValerieTse/ParadoxMap_ClaudeScienceHackathon
- **Demo video:** https://youtu.be/S3pV6QazTSM
- **Gallery:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery
- **Page:** https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/101

I set out to test whether the IL-23/IL-17 therapeutic paradox — the same pathway helping in one organ and harming in another — has a measurable tissue-intrinsic signature in public single-cell atlases, using a preregistered, blinded framework across gut, psoriatic skin, and HS.
The scientific result is honest and bounded: the cross-tissue comparison is not computable from current public data — psoriasis and HS are absent from the public single-cell disease vocabulary entirely — and the within-tissue P comparison is underpowered rather than null. What survives is reference-free and real: a large IL23R-negative effector reserve, and tissue-specific co-activation (gut IL-23+IL-1, skin IL-23+TCR).
The deeper output is methodological. Working with Claude Science, I logged nine data-integrity defects, none caught by any automated check — each one about what a number counts, not whether it computes. Deciding what is true, it turns out, is still the human's job. That discipline is the transferable result.

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Markdown version of https://cerebralvalley.ai/e/built-with-claude-life-sciences/hackathon/gallery/101. Site index for agents: https://cerebralvalley.ai/llms.txt · full text: https://cerebralvalley.ai/llms-full.txt